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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46342

Title: Effects of chitosan oligosaccharides on drug-metabolizing enzymes in rat liver and kidneys
Authors: Hsien-Tsung Yao;Mei-Ning Luo;Lang-Bang Hung;Meng-Tsan Chiang;Jia-Hsuan Lin;C K Lii;Chun-Yin Huang
Contributors: 國立臺灣海洋大學:食品科學系
Date: 2012
Issue Date: 2018-05-16T07:32:42Z
Publisher: Food and chemical toxicology
Abstract: Abstract: To investigate the effect of chitosan oligosaccharides (COS) on drug-metabolizing enzymes in rat liver and kidneys, male Spraque-Dawley rats were fed a diet containing 1% or 3% COS for 5 weeks. The activities of cytochrome P450 (CYP) enzymes, UDP-glucurosyltransferase (UGT) and glutathione S-transferase (GST) in the liver and kidneys were determined. Significant decreases in microsomal CYP3A-catalyzed testosterone 6β-hydroxylation, CYP2C-catalyzed diclofenac 4-hydroxylation, and CYP4A-catalyzed lauric acid 12-hydroxylation in the liver of rats fed the COS diets were observed compared with those rats fed the control diet. Immunoblot analyses of CYP proteins showed the same trend as with enzyme activities. Increased glutathione content in liver was found in rats fed the 1% COS diet. Increased hepatic NADPH: quinone oxidoreductase 1 (NQO1) activity was found in rats fed the COS diets. In kidneys, COS had little or no effect on CYP enzyme activities. However, increased GST activity was observed in rats fed the COS diets. Moreover, a higher UGT activity was found in rats fed the 1% COS diet. Our results indicate that COS may suppress hepatic CYP enzymes and induce phase II detoxifying reactions in the liver and kidneys of rats.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46342
Appears in Collections:[食品科學系] 期刊論文

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