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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46339

Title: Supplementation of chitosan alleviates high-fat diet-enhanced lipogenesis in rats via AMP-activated protein kinase activation and inhibition of lipogenesis-associated genes
Authors: Chen-Yuan Chiu
Im-Lam Chan
Tsung-Han Yang
Shing-Hwa Liu
Meng-Tsan Chiang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: lipogenesis
chitosan
AMP-activated protein kinase
gene expression
high-fat diet
Date: 2015
Issue Date: 2018-05-16T07:13:09Z
Publisher: Journal of Agricultural and Food Chemistry
Abstract: Abstract: This study investigated the role of chitosan in lipogenesis in high-fat diet-induced obese rats. The lipogenesis-associated genes and their upstream regulatory proteins were explored. Diet supplementation of chitosan efficiently decreased the increased weights in body, livers, and adipose tissues in high-fat diet-fed rats. Chitosan supplementation significantly raised the lipolysis rate; attenuated the adipocyte hypertrophy, triglyceride accumulation, and lipoprotein lipase activity in epididymal adipose tissues; and decreased hepatic enzyme activities of lipid biosynthesis. Chitosan supplementation significantly activated adenosine monophosphate (AMP)-activated protein kinase (AMPK) phosphorylation and attenuated high-fat diet-induced protein expressions of lipogenic transcription factors (PPAR-γ and SREBP1c) in livers and adipose tissues. Moreover, chitosan supplementation significantly inhibited the expressions of downstream lipogenic genes (FAS, HMGCR, FATP1, and FABP4) in livers and adipose tissues of high-fat diet-fed rats. These results demonstrate for the first time that chitosan supplementation alleviates high-fat diet-enhanced lipogenesis in rats via AMPK activation and lipogenesis-associated gene inhibition.
Relation: 63(11) pp.2979–2988
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46339
Appears in Collections:[食品科學系] 期刊論文

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