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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46337

Title: Long-Term Feeding of Chitosan Ameliorate Glucose and Lipid Metabolism in a High-Fructose-Diet-Impaired Glucose-Tolerance Rat Model
Authors: Hshuan-Chen,Liu
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: plasma lipids
insulin resistance
liver lipids
Date: 2017
Issue Date: 2018-05-16T06:40:33Z
Publisher: Journal of Food and Drug Analysis
Abstract: Abstract: This study was designed to investigate the effect of Gelidium amansii (GA) on carbohydrate and lipid metabolism in rats with high fructose (HF) diet (57.1% w/w). Five-week-old male Sprague-Dawley rats were fed a HF diet to induce glucose intolerance and hyperlipidemia. The experiment was divided into three groups: (1) control diet group (Con); (2) HF diet group (HF); and (3) HF with GA diet group (HF + 5% GA). The rats were fed the experimental diets and drinking water ad libitum for 23 weeks. The results showed that GA significantly decreased retroperitoneal fat mass weight of HF diet-fed rats. Supplementation of GA caused a decrease in plasma glucose, insulin, tumor necrosis factor-α, and leptin. HF diet increased hepatic lipid content. However, intake of GA reduced the accumulation of hepatic lipids including total cholesterol (TC) and triglyceride contents. GA elevated the excretion of fecal lipids and bile acid in HF diet-fed rats. Furthermore, GA significantly decreased plasma TC, triglyceride, low density lipoprotein plus very low density lipoprotein cholesterol, and TC/high density lipoprotein cholesterol ratio in HF diet-fed rats. HF diet induced an in plasma glucose and an impaired glucose tolerance, but GA supplementation decreased homeostasis model assessment equation-insulin resistance and improved impairment of glucose tolerance. Taken together, these results indicate that supplementation of GA can improve the impairment of glucose and lipid metabolism in an HF diet-fed rat model.
Relation: 25(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46337
Appears in Collections:[食品科學系] 期刊論文

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