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题名: The regulatory effects of fish oil and chitosan on hepatic lipogenic signals in high-fat diet-induced obese rats.
作者: Chen-Yuan,Chiu
Tien-Chia,Chang
Shing-Hwa,Liu
Meng-Tsan,Chiang
贡献者: 國立臺灣海洋大學:食品科學系
关键词: lipogenesis
fish oil
chitosan
gene expression
shigh-fat diet
日期: 2017
上传时间: 2018-05-16T06:12:48Z
出版者: Journal of Food and Drug Analysis
摘要: Abstract: The present study investigated the regulatory effects of fish oil and chitosan on the signals of hepatic lipid metabolism and the postulated mechanism in high-fat diet-induced obese rats. Diet supplementation of chitosan and fish oil efficiently suppressed the increased weights in body and livers of high-fat diet-fed rats. Supplementation of chitosan and fish oil significantly decreased the activities of hepatic lipid biosynthesis-related enzymes and efficiently regulated plasma lipoprotein homeostasis. Both chitosan and fish oil significantly ameliorated the alterations in the protein expressions of hepatic lipogenic transcription factors (LXRα and PPARα), and could also significantly regulate the downstream hepatic lipogenic genes (FAS, HMGCR, CYP7A1, FATP, FABP, AOX, and ABCA) expressions in high-fat diet-fed rats. These results suggest that both fish oil and chitosan exerts downregulative effects on hepatic lipid metabolism in high-fat diet-induced obese rats via the LXRα inhibition and PPARα activation, which further affect the expressions of hepatic lipogenesis-associated genes.
關聯: 25(4) pp.910-930
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46334
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