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題名: Red algae (Gelidium amansii) hot water extracts ameliorate lipid metabolism in hamsters fed a high fat diet
作者: Tsung-Han,Yang
Hsien-Tsung,Yao
Meng-Tsan,Chiang
貢獻者: 國立臺灣海洋大學:食品科學系
關鍵詞: sterol regulatory element-binding proteins
Gelidium amansii hot-water extract
AMP-activated protein kinase
hamsters
lipid metabolism
日期: 2017
上傳時間: 2018-05-16T06:03:30Z
出版者: Journal of Food and Drug Analysis
摘要: Abstract: The purpose of this study was to investigate the effects of Gelidium amansii (GA) hot-water extracts (GHE) on lipid metabolism in hamsters. Six-week-old male Syrian hamsters were used as the experimental animals. Hamsters were divided into four groups: (1) control diet group (CON); (2) high-fat diet group (HF); (3) HF with GHE diet group (HF + GHE); (4) HF with probucol diet group (HF + PO). All groups were fed the experimental diets and drinking water ad libitum for 6 weeks. The results showed that GHE significantly decreased body weight, liver weight, and adipose tissue (perirenal and paraepididymal) weight. The HF diet induced an increase in plasma triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein cholesterol and very-low-density lipoprotein cholesterol levels. However, GHE supplementation reversed the increase of plasma lipids caused by the HF diet. In addition, GHE increased fecal cholesterol, TG and bile acid excretion. Lower hepatic TC and TG levels were found with GHE treatment. GHE reduced hepatic sterol regulatory element-binding proteins (SREBP) including SREBP 1 and SREBP 2 protein expressions. The phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) protein expression in hamsters was decreased by the HF diet; however, GHE supplementation increased the phosphorylation of AMPK protein expression. Our results suggest that GHE may ameliorate lipid metabolism in hamsters fed a HF diet.
關聯: 25(4) pp.931-938
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46333
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