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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46321

Title: Breast Tumor Microenvironment: Proteomics Highlights the Treatments Targeting Secretome
Authors: Shui-Tein Chen
Tai-Long Pan
Hsueh-Fen Juan
Tai-Yuan Chen
Yih-Shyan Lin
Chun-Ming Huang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: extracellular matrix
breast cancer
tumor microenvironment
Date: 2008
Issue Date: 2018-05-15T08:11:03Z
Publisher: Journal of Proteome Research
Abstract: Abstract: Tumor secreted substances (secretome), including extracellular matrix (ECM) components, act as mediators of tumor−host communication in the breast tumor microenvironment. Proteomic analysis has emphasized the value of the secretome as a source of prospective markers and drug targets for the treatment of breast cancers. Utilizing bioinformatics, our recent studies revealed global changes in protein expression after the activation of ECM-mediated signaling in breast cancer cells. A newly designed technique integrating a capillary ultrafiltration (CUF) probe with mass spectrometry was demonstrated to dynamically sample and identify in vivo and pure secretome from the tumor microenvironment. Such in vivo profiling of breast cancer secretomes may facilitate the development of novel drugs specifically targeting secretome.
Relation: 7(4) pp.1379–1387
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46321
Appears in Collections:[食品科學系] 期刊論文

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