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Title: Inhibition of Lipopolysaccharide (LPS)-Induced Inflammatory Responses by Sargassum hemiphyllum Sulfated Polysaccharide Extract in RAW 264.7
Authors: Pai-An Hwang
Shih-Yung Chien
Yi-Lin Chan
Mei-Kuang Lu
Chwen-Herng Wu
Zwe-Ling Kong
Chang-Jer Wu
Contributors: 國立臺灣海洋大學:海洋生物研究所
Date: 2011
Issue Date: 2018-05-15T07:21:14Z
Publisher: Journal of Agricultural and Food Chemistry
Abstract: Abstract: Sargassum hemiphyllum, a kind of brown seaweed generally found along coastlines in East Asia, has long served as a traditional Chinese medicine. S. hemiphyllum has shown an anti-inflammatory effect; however, its mechanism has not been elucidated clearly. This study explored S. hemiphyllum for its biomedical effects. S. hemiphyllum sulfated polysaccharide extract (SHSP) was first prepared; the mouse macrophage cell line (RAW 264.7) activated by lipopolysaccharide (LPS) was used as a model system. The secretion profiles of pro-inflammatory cytokines, including IL-1β, IL-6, TNF-α, and NO, were found significantly to be reduced in 1−5 mg/mL dose ranges of SHSP treatments. RT-PCR analysis suggested SHSP inhibits the LPS-induced mRNA expressions of IL-β, iNOS, and COX-2 in a dose-dependent manner. At protein levels, Western blot analysis demonstrated a similar result for NF-κB (p65) in cytosol/nuclear. Taken together, the anti-inflammatory properties of SHSP may be attributed to the down-regulation of NF-κB in nucleus.
Relation: 59(5) pp.2062–2068
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46317
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