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Title: The Repair Ability of Nanocurcumin in Oral on Hamster Sperm Damage Caused by Cisplatin
Authors: H.-P. Kuo
M.-C. Chen
Z.-L. Kong
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: real-time polymerase chain reaction
magnetic nanoparticles
immunomagnetic reduction
Date: 2015
Issue Date: 2018-05-15T06:49:27Z
Publisher: Taiwanese Journal of Agricultural Chemistry and Food Science
Abstract: Abstract: Sperm damage caused by oxidative stress is one of the main reasons for male infertility. Researches had shown that curcumin has many activities including anti-oxidation and anti-inflammation; however, the clinical data indicate that it is a very low bio-available and unstable compound. In this study, the curcumin nanoparticles (Nanocurcumin, NACU) fabricated by chitosan and silica were investigated for the effect of repair ability in a hamster reproductive capacity which damaged by cisplatin (CP). It was found that an appropriate dosage of NACU can effectively increase the sperm concentration, motility and reduce the proportion of abnormal sperms. NACU can also significantly reduce the excess ROS caused by CP in sperm and MDA content in plasma, testicular and sperm. We have clarified the ability of the nanocurcumin to repair sperm damage by reducing oxidative stress and NACU can be used as a potential health product to prevent male infertility. © 2015, Chinese Agricultural Chemical Society. All rights reserved.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46315
Appears in Collections:[食品科學系] 期刊論文

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