English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26988/38789
Visitors : 2346021      Online Users : 24
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45928

Title: Screening mangrove endophytic fungi for antimalarial natural products.
Authors: Laurent Calcul
Carrie Waterman
Wai Sheung Ma
Matthew D. Lebar
Charles Harter
Tina Mutka
Lindsay Morton
Patrick Maignan
Alberto Van Olphen
Dennis E. Kyle
Lilian Vrijmoed
Ka-Lai Pang
Cedric Pearce
Bill J. Baker
Contributors: 國立臺灣海洋大學:海洋生物研究所
Keywords: endophytes
fungi
mangroves
malaria
cytotoxicity
high-throughput
Date: 2013
Issue Date: 2018-04-17T07:59:08Z
Publisher: Marine Drugs
Abstract: Abstract: We conducted a screening campaign to investigate fungi as a source for new antimalarial compounds. A subset of our fungal collection comprising Chinese mangrove endophytes provided over 5000 lipophilic extracts. We developed an accelerated discovery program based on small-scale cultivation for crude extract screening and a high-throughput malaria assay. Criteria for hits were developed and high priority hits were subjected to scale-up cultivation. Extracts from large scale cultivation were fractionated and these fractions subjected to both in vitro malaria and cytotoxicity screening. Criteria for advancing fractions to purification were developed, including the introduction of a selectivity index and by dereplication of known metabolites. From the Chinese mangrove endophytes, four new compounds (14–16, 18) were isolated including a new dimeric tetrahydroxanthone, dicerandrol D (14), which was found to display the most favorable bioactivity profile.
Relation: 11(12) 5036-5050
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45928
Appears in Collections:[海洋生物研究所] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML41View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback