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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45904

Title: Hirsutane-type sesquiterpenes with inhibitory activity of microglial nitric oxide production from the red alga-derived fungus Chondrostereum sp. NTOU4196
Authors: George Hsiao;Wei-Chiung Chi;Ka-Lai Pang;Jih-Jung Chen;Yueh-Hsiung Kuo;Yu-Kai Wang;Hyo-Jung Cha;Shen-Chieh Chou;Tzong-Huei Lee
Contributors: 國立臺灣海洋大學:海洋生物研究所
Date: 2017
Issue Date: 2018-04-16T08:19:00Z
Publisher: Journal of Natural Products
Abstract: Abstract: The marine red alga Pterocladiella capillacea is an economic alga for the food industry in Taiwan, and its associated highly diversified fungi have not been investigated meticulously thus far. The EtOAc extract of the fermented broth of Chondrostereum sp. NTOU4196, a fungal strain isolated from P. capillacea, was found to exhibit significant nitric oxide (NO) production inhibitory activity in lipopolysaccharide-activated murine RAW 264.7 cells at a concentration of 100 μg/mL in the preliminary screening. Therefore, separation of the active principles from the fermented broths was performed, and that has led to the isolation of eight new 5,5,5-tricyclic hirsutane-type sesquiterpenes, namely, chondroterpenes A–H (1–8), together with seven known analogues. They were identified by analyses of spectroscopic data and comparison with literature values. Among the new isolates, chondroterpene A (1) exhibited more significant NO production inhibitory activity in murine BV-2 microglial cells, and of all the isolated compounds, hirsutanol A (9) exerted limited cytotoxic effects and the most potent inhibitory activity on NO production.
Relation: 80(5) pp.1615-1622
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45904
Appears in Collections:[海洋生物研究所] 期刊論文

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