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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45588

Title: Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells.
Authors: Hwang, P. A.
Phan, N. N.
u, W. J.
Hieu, B. T. N.
Lin, Y. C.
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: prebiotics
fucoxanthin
anti-inflammatory
low-molecular-weight fucoidan
Date: 2016
Issue Date: 2018-03-27T07:41:59Z
Publisher: Food and Nutrition Research
Abstract: Abstract:
BACKGROUND:
The aim of this study is to investigate the anti-inflammatory effects of low-molecular-weight fucoidan (LMF) and high-stability fucoxanthin (HS-Fucox) in a lipopolysaccharide-induced inflammatory Caco-2 cell line co-culture with B. lactis.

METHODS:
We used various methods such as transepithelial resistance (TER) assay, cytokine secretion assay, and tight junction protein mRNA expression assay to examine LMF and HS-Fucox anti-inflammatory properties.

RESULTS:
LMF and HS-Fucox activated probiotic growth and reduced the inflammation of the intestinal epithelial cells. Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1β and TNF-α and promoting IL-10 and IFN-γ.

CONCLUSION:
These findings suggested that LMF and HS-Fucox, alone or in combination, could be the potential natural compounds to enhance the immune system and have an anti-inflammatory effect on the intestinal cells.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45588
Appears in Collections:[生命科學系] 期刊論文

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