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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45550

Title: SUMOylation of Blimp-1 is critical for plasma cell differentiation
Authors: Hsia‐Yuan Ying;Shin‐Tang Su;Pang‐Hung Hsu;Che‐Chang Chang;I‐Ying Lin;Yu‐Hsuan Tseng;Ming‐Daw Tsai;Hsiu‐Ming Shih;Kuo‐I Lin
Contributors: 國立臺灣海洋大學:生命科學系
Date: 2013
Issue Date: 2018-03-26T06:20:55Z
Publisher: EMBO Report
Abstract: Abstract: Transcriptional repressor B lymphocyte‐induced maturation protein‐1 (Blimp‐1) is a master regulator of plasma cell differentiation. Here we show that Blimp‐1 is covalently modified by SUMO1 at lysine 816, a modification mediated by SUMO E3 ligase PIAS1. Mutation of Blimp‐1 lysine 816 reduces transcriptional repression—correlating with a reduced interaction with a histone deacetylase, HDAC2—and impairs differentiation of antibody‐secreting cells. Thus, the SUMO pathway critically regulates Blimp‐1 function during plasma cell differentiation.
Relation: 13(7)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45550
Appears in Collections:[生命科學系] 期刊論文

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