English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26988/38789
Visitors : 2345960      Online Users : 37
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45546

Title: BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.
Authors: Po-Han Chen
Chia-I Lee
Yu-Tzu Weng
Woan-Yuh Tarn
Yeou-Ping Tsao
Ping-Chang Kuo
Pang-Hung Hsu
Chu-Wei Huang
Chiun-Sheng Huang
Hsiu-Hsiang Lee
June-Tai Wu
Show-Li Chen
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Drosophila
BCAS2
viability
splicing
Prp19
complex
Date: 2013
Issue Date: 2018-03-26T05:53:21Z
Publisher: RNA
Abstract: Abstract: Here, we show that dBCAS2 (CG4980, human Breast Carcinoma Amplified Sequence 2 ortholog) is essential for the viability of Drosophila melanogaster. We find that ubiquitous or tissue-specific depletion of dBCAS2 leads to larval lethality, wing deformities, impaired splicing, and apoptosis. More importantly, overexpression of hBCAS2 rescues these defects. Furthermore, the C-terminal coiled-coil domain of hBCAS2 binds directly to CDC5L and recruits hPrp19/PLRG1 to form a core complex for splicing in mammalian cells and can partially restore wing damage induced by knocking down dBCAS2 in flies. In summary, Drosophila and human BCAS2 share a similar function in RNA splicing, which affects cell viability.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45546
Appears in Collections:[生命科學系] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML69View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback