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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45546

Title: BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing.
Authors: Po-Han Chen
Chia-I Lee
Yu-Tzu Weng
Woan-Yuh Tarn
Yeou-Ping Tsao
Ping-Chang Kuo
Pang-Hung Hsu
Chu-Wei Huang
Chiun-Sheng Huang
Hsiu-Hsiang Lee
June-Tai Wu
Show-Li Chen
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Drosophila
Date: 2013
Issue Date: 2018-03-26T05:53:21Z
Publisher: RNA
Abstract: Abstract: Here, we show that dBCAS2 (CG4980, human Breast Carcinoma Amplified Sequence 2 ortholog) is essential for the viability of Drosophila melanogaster. We find that ubiquitous or tissue-specific depletion of dBCAS2 leads to larval lethality, wing deformities, impaired splicing, and apoptosis. More importantly, overexpression of hBCAS2 rescues these defects. Furthermore, the C-terminal coiled-coil domain of hBCAS2 binds directly to CDC5L and recruits hPrp19/PLRG1 to form a core complex for splicing in mammalian cells and can partially restore wing damage induced by knocking down dBCAS2 in flies. In summary, Drosophila and human BCAS2 share a similar function in RNA splicing, which affects cell viability.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45546
Appears in Collections:[生命科學系] 期刊論文

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