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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45497

Title: NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress
Authors: Po-Jen Chen;Jui-Yun Weng;Pang-Hung Hsu;Jin-Yuh Shew;Yi-Shuian Huang;Wen-Hwa Lee
Contributors: 國立臺灣海洋大學:生命科學系
Date: 2015
Issue Date: 2018-03-22T01:48:17Z
Publisher: Nucleic Acids Research
Abstract: Abstract: Non-selenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx or GPx7) is an oxidative stress sensor that modulates the antioxidative activity of its target proteins through intermolecular disulfide bond formation. Given NPGPx's role in protecting cells from oxidative damage, identification of the oxidative stress-induced protein complexes, which forms with key stress factors, may offer novel insight into intracellular reactive oxygen species homeostasis. Here, we show that NPGPx forms a disulfide bond with the translational regulator cytoplasmic polyadenylation element-binding protein 2 (CPEB2) that results in negative regulation of hypoxia-inducible factor 1-alpha (HIF-1α) RNA translation. In NPGPx-proficient cells, high oxidative stress that disrupts this bonding compromises the association of CPEB2 with HIF-1α RNA, leading to elevated HIF-1α RNA translation. NPGPx-deficient cells, in contrast, demonstrate increased HIF-1α RNA translation under normoxia with both impaired induction of HIF-1α synthesis and blunted HIF-1α-programmed transcription following oxidative stress. Together, these results reveal a molecular mechanism for how NPGPx mediates CPEB2-controlled HIF-1α RNA translation in a redox-sensitive manner.
Relation: 43(19)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45497
Appears in Collections:[生命科學系] 期刊論文

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