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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45479

Title: Consecutive Evaluation of Graphene Oxide and Reduced Graphene Oxide Nanoplatelets Immunotoxicity on Monocytes.
Authors: Junyan Yan
Liliang Chen
Chih-Ching Huang
Shih-Chun Candice Lung
Lingyan Yang
Wen-Cheng Wang
Po-Hsiung Lin
Guangli Suo
Chia-Hua Lin
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Surface oxidation state
Graphene oxide
Monocyte-derived macrophages
Date: 2017
Issue Date: 2018-03-21T06:09:26Z
Publisher: Colloids and Surfaces B: Biointerfaces
Abstract: Abstract: The biocompatibilities of graphene-family nanomaterials (GFNs) should be thoroughly evaluated before their application in drug delivery and anticancer therapy. The present study aimed to consecutively assess the immunotoxicity of graphene oxide nanoplatelets (GONPs) and reduced GONPs (rGONPs) on THP-1 cells, a human acute monocytic leukemia cell line. GONPs induced the expression of antioxidative enzymes and inflammatory factors, whereas rGONPs had substantially higher cellular uptake rate, higher levels of NF-κB expression. These distinct toxic mechanisms were observed because the two nanomaterials differ in their oxidation state, which imparts different affinities for the cell membrane. Because GONPs have a higher cell membrane affinity and higher impact on membrane proteins compared with rGONPs, macrophages (THP-1a) derived from GONPs treated THP-1cells showed a severer effect on phagocytosis. By consecutive evaluation the effects of GONPs and rGONPs on THP-1 and THP-1a, we demonstrated that their surface oxidation states may cause GFNs to behave differently and cause different immunotoxic effects.
Relation: 153(1)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45479
Appears in Collections:[生命科學系] 期刊論文

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