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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45461

Title: Role of Tec kinase in nuclear factor of activated T cells (NFAT) signaling.
Authors: Yang WC;Ghiotto M;Castellano R;Collette Y;Auphan N;Nunès JA;Olive D
Contributors: 國立臺灣海洋大學:水產養殖學系
Date: 2000
Issue Date: 2018-03-19T08:21:49Z
Publisher: Journal of International Immunology
Abstract: Abstract
The Tec protein kinase family includes Btk, Itk, Tec, Rlk and Bmx, which are critically involved in signals mediated by various cytokines and antigen receptors. Btk mutations cause severe immunodeficiencies, with defective B cell function. In T cells, Tec regulates cytokine production. However, the downstream targets of these Tec kinases are poorly defined. Here we report that overexpression of Tec in T cells can regulate gene transcription through the nuclear factor of activated T cells (NF-AT). Using different reporter gene constructs, we establish that Tec in transfected T cells dramatically induced NF-AT-dependent gene transcription, which was prevented by a dominant-negative mutant of NF-AT or by the immunosuppressive drug cyclosporin A. Tec appears to regulate NF-AT nuclear import. In addition, Tec influences cytoplasmic free calcium increase. Taken together, our results identify NF-AT as a major downstream target of Tec kinases that is critically involved in transcriptional gene regulation. These observations highlight signaling pathways regulated by Tec kinases and provide new pharmacological targets to regulate immune functions.
Relation: 12(11)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45461
Appears in Collections:[水產養殖學系] 期刊論文

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