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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45458

Title: Polyacetylenic compound and butanol fraction from Bidens pilosa Linn. can modulate the differentiation of helper T cells and prevent autoimmune diabetes in non-obese diabetic mice.
Authors: Shu-Lin Chang;Cicero Lee-Tian Chang;Yi-Ming Chiang;Rong-Hong Hsieh;Chii-Ruey Tzeng;Tung-Kung Wu;Huey-Kang Sytwu;Lie-Fen Shyur;Wen-Chin Yang
Contributors: 國立臺灣海洋大學:水產養殖學系
Date: 2004
Issue Date: 2018-03-19T08:08:40Z
Publisher: Planta Medica
Abstract: Abstract: Compelling evidence suggests that infiltrating CD4+ type I helper T (Th1) cells in the pancreatic islets play a pivotal role in the progression of diabetes in non-obese diabetic (NOD) mice. We demonstrate in the present report that a butanol fraction of B. pilosa suppressed the development of diabetes, helped maintain levels of blood sugar and insulin in NOD mice in a dose-dependent manner and elevated the serum IgE levels regulated by Th2 cytokines in NOD mice. Moreover, the butanol fraction inhibited the differentiation of naïve helper T (Th0) cells into Th1 cells but enhanced their transition into type II helper T (Th2) cells using an in vitro T cell differentiation assay. Two polyacetylenic compounds, 2-β-D-glucopyranosyloxy-1-hydroxy-5(E)-tridecene-7,9,11-triyne and 3-β-D-glucopyranosyloxy-1-hydroxy-6(E)-tetradecene-8,10,12-triyne, identified from the butanol fraction also prevented the onset of diabetes like the butanol fraction. The latter compound showed a stronger activity for T cell differentiation than the former. In summary, the butanol fraction of B. pilosa and its polyacetylenes can prevent diabetes plausibly via suppressing the differentiation of Th0 cells into Th1 cells and promoting that of Th0 cells into Th2 cells.
Relation: 70(11)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45458
Appears in Collections:[水產養殖學系] 期刊論文

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