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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45455

Title: Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
Authors: Yi-Ming Chiang
Cicero Lee-Tian Chang
Shu-Lin Chang
Wen-Chin Yang
Lie-Fen Shyur
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: T cell differentiation
Polyacetylenic glucoside
Bidens pilosa
Date: 2007
Issue Date: 2018-03-19T07:52:30Z
Publisher: Journal of Ethnopharmacology
Abstract: Abstract: An extract of Bidens pilosa, an anti-diabetic Asteraceae plant, has recently been reported to modulate T cell differentiation and prevent the development of non-obese diabetes (NOD) in NOD mice. In this paper, a novel bioactive polyacetylenic glucoside, cytopiloyne (1), was identified from the Bidens pilosa extract using ex vivo T cell differentiation assays based on a bioactivity-guided fractionation and isolation procedure. Its structure was elucidated as 2β-d-glucopyranosyloxy-1-hydroxytrideca-5,7,9,11-tetrayne by various spectroscopic methods. Functional studies showed that cytopiloyne was able to inhibit the differentiation of naïve T helper (Th0) cells into type I T helper (Th1) cells but to promote the differentiation of Th0 cells into type II T helper (Th2) cell. Accordingly, cytopiloyne also suppressed IFN-γ expression and promoted IL-4 expression in mouse splenocytes ex vivo. These results suggest that cytopiloyne functions as a T cell modulator that may directly contribute to the ethnopharmacological effect of Bidens pilosa extract on preventing diabetes. Moreover, cytopiloyne can serve as an index compound for quality control of lot-to-lot extract preparations of Bidens pilosa.
Relation: 110(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45455
Appears in Collections:[水產養殖學系] 期刊論文

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