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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45454

Title: The effect of centaurein on interferon-γ expression and Listeria infection in mice.
Authors: Shu-Lin Chang
Hsu-Hua Yeh
Yu-Shiun Lin
Yi-Ming Chiang
Tung-Kung Wu
Wen-Chin Yang
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: Flavonoid
IFN-γ
Centaurein
Listeria
Date: 2007
Issue Date: 2018-03-19T07:52:17Z
Publisher: Toxicology and Applied Pharmacology
Abstract: Abstract: We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
Relation: 219(1)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45454
Appears in Collections:[水產養殖學系] 期刊論文

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