English  |  正體中文  |  简体中文  |  Items with full text/Total items : 28607/40644
Visitors : 4771251      Online Users : 206
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45454

Title: The effect of centaurein on interferon-γ expression and Listeria infection in mice.
Authors: Shu-Lin Chang
Hsu-Hua Yeh
Yu-Shiun Lin
Yi-Ming Chiang
Tung-Kung Wu
Wen-Chin Yang
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: Flavonoid
Date: 2007
Issue Date: 2018-03-19T07:52:17Z
Publisher: Toxicology and Applied Pharmacology
Abstract: Abstract: We previously found that centaurein enhanced IFN-γ transcription in T cells. Here, we demonstrate that centaurein increased the IFN-γ expression in T and NK cells and the serum IFN-γ level in mice. Centaurein elevated the transcription of T-bet but not GATA-3, which is consistent with its effect on that of IFN-γ but not IL-4. Additionally, centaurein effectively protected mice against Listeria infection. Moreover, centaurein per se or in combination with antibiotics could treat Listeria infection. Our mechanistic studies suggest that centaurein augments IFN-γ expression via a transcriptional up-regulation of T-bet and that centaurein protects against or treats Listeria infection via a modulation of IFN-γ expression.
Relation: 219(1)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45454
Appears in Collections:[水產養殖學系] 期刊論文

Files in This Item:

File Description SizeFormat

All items in NTOUR are protected by copyright, with all rights reserved.


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback