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Title: Role of Cybr, a cytohesin binder and regulator, in CD4+ T-cell function and host immunity.
Authors: Shu-Lin Chang
C. Lee-Tian Chang
Pei-Ing Huang
Mi-Hua Tao
Wen-Chin Yang
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: Transgenic mice
MAP kinase
T cells
Date: 2009
Issue Date: 2018-03-19T07:03:08Z
Publisher: Molecular Immunology
Abstract: Abstract: Cytohesin binder and regulator (Cybr) is known to regulate leukocyte adhesion and migration. However, its function in T-cells is poorly understood. Here, we investigated the role of Cybr in CD4+ T-cell function and host immunity. Cybr inhibited p38 phosphorylation following CD4+ T-cell stimulation. Since p38 regulates the expression of T-box expressed in T-cells (T-bet) but not GATA binding protein 3 (GATA-3) in T-cells, Cybr decreased the expression of T-bet and IFN-γ in CD4+ T-cells. Moreover, we found that host immunity against Listeria infection and IFN-γ production in blood were significantly compromised in Cybr-overexpressing transgenic mice. In summary, our data suggest that Cybr represses the expression of T-bet and IFN-γ via an inhibition of p38 in T-cells and consequently reduces host resistance to bacterial infection in mice.
Relation: 46(16)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45450
Appears in Collections:[水產養殖學系] 期刊論文

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