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题名: Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine.
作者: Chen HM
Wang PH
Chen SS
Wen CC
Chen YH
Yang WC
Yang NS.
贡献者: 國立臺灣海洋大學:水產養殖學系
关键词: Cancer vaccine
Shikonin
Immunogenic cell death
Damage-associated molecular pattern
Dendritic cells
日期: 2012
上传时间: 2018-03-19T06:35:43Z
出版者: Cancer Immunology, Immunotherapy
摘要: Abstract: Immunogenic cell death is characterized by damage-associated molecular patterns, which can enhance the maturation and antigen uptake of dendritic cells. Shikonin, an anti-inflammatory and antitumor phytochemical, was exploited here as an adjuvant for dendritic cell-based cancer vaccines via induction of immunogenic cell death. Shikonin can effectively activate both receptor- and mitochondria-mediated apoptosis and increase the expression of all five tested damage-associated molecular patterns in the resultant tumor cell lysates. The combination treatment with damage-associated molecular patterns and LPS activates dendritic cells to a high maturation status and enhances the priming of Th1/Th17 effector cells. Shikonin-tumor cell lysate-loaded mature dendritic cells exhibit a high level of CD86 and MHC class II and activate Th1 cells. The shikonin-tumor cell lysate-loaded dendritic cell vaccines result in a strong induction of cytotoxic activity of splenocytes against target tumor cells, a retardation in tumor growth, and an increase in the survival of test mice. The much enhanced immunogenicity and efficacy of the current cancer vaccine formulation, that is, the use of shikonin-treated tumor cells as cell lysates for the pulse of dendritic cells in culture, may suggest a new ex vivo approach for developing individualized, dendritic cells-based anticancer vaccines.
關聯: 61(11)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45444
显示于类别:[水產養殖學系] 期刊論文

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