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Title: Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK Pathways.
Authors: Yang CW
Chang CL, Lee HC
Chi CW
Pan JP
Yang WC.
Contributors: 國立臺灣海洋大學:水產養殖學系
Keywords: Acute Monocytic Leukemia Cell Line
Acute Myeloid Leukemia
Monocytic Leukemia
Acute Monocytic Leukemia
Date: 2012
Issue Date: 2018-03-19T06:31:58Z
Publisher: BMC Complementary and Alternative Medicine
Abstract: Abstract
Curcumin is a principal compound of turmeric, commonly used to treat tumors and other diseases. However, its anti-cancer activity in human acute monocytic leukemia THP-1 cells is not clear. This study aimed to study the anti-cancer effect and action of curcumin on THP-1 cells.

THP-1 parental cells and PMA-treated THP-1 cells, were used as in vitro models to evaluate the anti-cancer effect and mechanism of curcumin. Apoptosis and its mechanism were evaluated by WST-1, flow cytometry and Western blotting. MAPK inhibitors were used to further confirm the molecular mechanism of curcumin-induced THP-1 cell apoptosis.

Curcumin induced cell apoptosis of THP-1 cells as shown by cell viability, cell cycle analysis and caspase activity. Curcumin significantly increased the phosphorylation of ERK, JNK and their downstream molecules (c-Jun and Jun B). Inhibitor of JNK and ERK reduced the pro-apoptotic effect of curcumin on THP-1 cells as evidenced by caspase activity and the activation of ERK/JNK/Jun cascades. On the contrary, the pro-apoptotic effect of curcumin was abolished in the differentiated THP-1 cells mediated by PMA.

This study demonstrates that curcumin can induce the THP-1 cell apoptosis through the activation of JNK/ERK/AP1 pathways. Besides, our data suggest its novel use as an anti-tumor agent in acute monocytic leukemia.
Relation: 12:22
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45443
Appears in Collections:[水產養殖學系] 期刊論文

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