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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45420

Title: Cytotoxic property of Streptocaulon baumii extracts and their isolated compounds against different human cancer cell lines
Authors: Arlene P. Bartolome
Irene M. Villaseñor
Yea-Lih Lin2, M. Daben J. Libardo
Alfredo M. Angeles-Boza
Wen-Chin Yang
Contributors: 國立臺灣海洋大學:水產養殖學系
Date: 2017
Issue Date: 2018-03-19T01:26:36Z
Publisher: Philippine Science Letters
Abstract: Abstract: Investigation of the antiproliferative property of Streptocaulon baumii Decne. (Apocynaceae) leaves showed that the hexane fraction nonselectively inhibits cell proliferation of BJ, A549, HCT116 and MCF-7 cell lines using WST-1 cell proliferation assay. In a bioassay- guided scheme, loliolide (1), luteolin 3ʹ-methoxy ether (2) and ursolic acid (3) were isolated. MTT assay indicated that ursolic acid has the highest cytotoxicity against HeLa, MDA-MB231, Cos7 and RAW264.7. The IC50 of the purified compounds against a panel of cell lines is in the low micromolar range. This is the first report on the cytotoxicity of S. baumii against cancer cells as well as the first report of the isolation of the three compounds from plants of the Streptocaulon genus.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/45420
Appears in Collections:[水產養殖學系] 期刊論文

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