English  |  正體中文  |  简体中文  |  Items with full text/Total items : 27228/39071
Visitors : 2411347      Online Users : 61
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/44252

Title: Linear epitope prediction for grouper iridovirus antigens
Authors: Tao-Chuan Shih
Tun-Wen Pai
Li-Ping Ho
Hsin-Yiu Chou
Contributors: 國立臺灣海洋大學:資訊工程學系
NTOU:Department of Computer Science and Engineering
Keywords: grouper iridovirus
linear epitope
conformational epitope
antgenicity
surface characteristics
Date: 2016-12
Issue Date: 2017-11-20T07:20:17Z
Publisher: IEEE proceedings of 2016 International Computer Symposium (ICS 2016)
Abstract: Abstract:The main goal of this study is to predict common and exclusive linear epitopes from two different grouper iridovirus protein sequences and launch their applications to vaccine design. The prediction mechanism is essentially based on integrating previously developed linear/conformational epitope prediction systems, the structural prediction system (Phyre2), and the sequencestructure alignment tools. The predicted two protein structures of iridovirus were aligned by a structure alignment system for identifying virtual structural variations. If the predicted linear epitopes appeared to be the variant geometrical conformations and located on protein surface, they could be assumed as exclusive epitope candidates. Inversely, the conserved linear epitopes located on surface with high antigenicity could be considered as common linear epitopes for vaccine design. Through combining both sequence and structural alignment results and surface structure validation, two conserved segments and one partial conserved segment were found suitable for designing as linear epitopes for the two different iridoviruses. In addition, both grouper iridovirus sequences possess one unique segment respectively, and which can be considered as exclusive liner epitope for each iridovirus. All these predicted linear epitopes would be evaluated by suitable biological experiments for further verification.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/44252
Appears in Collections:[資訊工程學系] 演講及研討會

Files in This Item:

File Description SizeFormat
index.html0KbHTML31View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback