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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43752

Title: Epidemiology of post-transplant malignancy in Asian renal transplant recipients: a population-based study
Authors: F.-Y. Hsiao
William Wei-Yuan Hsu
Contributors: 國立臺灣海洋大學:資訊工程學系
NTOU:Department of Computer Science and Engineering
Keywords: Renal transplantation
Post-transplant cancer
Immunosuppression agents
Date: 2013
Issue Date: 2017-10-30T08:10:53Z
Publisher: International Urology and Nephrology
Abstract: Abstract:

Objective
Using Taiwan’s National Health Insurance Research Database, this large population-based study was conducted to explore the incidences and risk factors of post-transplant malignancy in Asian renal transplant recipients.

Patients and methods
A total of 642 patients who firstly underwent renal transplant between January 1, 2000 and December 31, 2008 were identified from a 2 million cohort. The primary endpoint was a subsequent hospitalization with a primary diagnosis of malignancy (ICD-9-CM code: 140.xx-239.xx) after renal transplantation. All patients were followed until the occurrence of endpoints or the end of the study (December 31, 2010), whichever came first. Adjusted risks of post-transplant cancer were analyzed using Cox proportional hazards regression model. All models were adjusted for baseline characteristics, comorbid diseases, transplant year, and exposure to immunosuppressive agents.

Results
Among 642 renal transplant patients, 54 cancers (8.4 %) were identified. The median time between transplant and cancer diagnosis was 46.2 (range 8.5–107.4) months. Cancers of kidney and other unspecified urinary organs was the most common cancer sites, accounted for 18.5 % of the malignancies diagnosed. The next most common cancer sites were trachea, bronchus, and lung (14.8 %), bladder (13.0 %), liver and intrahepatic bile ducts (11.1 %), colon (5.6 %), and prostate (5.6 %). Age at transplantation was a statistically significant risk factor of post-transplant cancer in our study. Increased risks of post-transplant cancer were observed in patients who received immunosuppression agents (cyclosporine (HR 1.26, 95 % CI 0.58–2.77, p = 0.5603), tacrolimus (HR 1.99, 95 % CI 0.66–6.00, p = 0.2197), and mycophenolate (HR 1.00, 95 % CI 0.40–2.45, p = 0.9874)) although the estimates were not statistically significant.

Conclusions
Our population-based cohort study offers additional insight into post-transplant cancers in Asian population. Further studies are warranted to assess the association between specific immunosuppression agents and post-transplant cancers.
Relation: 46(4), pp 833–83
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43752
Appears in Collections:[資訊工程學系] 期刊論文

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