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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43576

Title: Inhibitory activity of Sargassum hemiphyllum sulfated polysaccharide in arachidonic acid-induced animal models of inflammation
Authors: Hwang, P. A.;Hung, Y. L.;Chien, S. Y.
Contributors: 國立臺灣海洋大學:生命科學系
Date: 2015-03-23
Issue Date: 2017-10-05T06:57:51Z
Publisher: Journal of Food and Drug Analysis
Abstract: Abstract:Sargassum hemiphyllum is a common plant found on the coasts of Taiwan; it has been used as an anti-inflammatory agent in traditional herbal medicine. This study aimed to evaluate the anti-inflammatory effects of S. hemiphyllum sulfated polysaccharide (SHSP) using two different mouse models. In both arachidonic acid-induced ear inflammatory gavage and paint models, SHSP decreased ear swelling and erythema. In addition, SHSP decreased the production of myeloperoxidase, nitric oxide, interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α in a dose-dependent manner. Histological examination results showed that SHSP reduced the area of neutrophilic infiltration in inflamed ears. The anti-inflammatory activity of SHSP has already been demonstrated in vitro. In this study, SHSP extracted from the same species of brown seaweed exhibited anti-inflammatory activity in both oral and topical applications in vivo. Therefore, SHSP may play a role in the treatment of inflammatory diseases.
Relation: 23, pp.49-56
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43576
Appears in Collections:[生命科學系] 期刊論文

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