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Title: A mechanism of low molecular weight fucoidans degraded by enzymatic and acidic hydrolysis for the prevention of UVB damage
Authors: Pai-An Hwang
Ming-De Yan
Ko-Liang Kuo
Nam Nhut Phan
Yen-Chang Lin
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Low molecular fucoidans;UV damage;TGFβRII;MMP genes
Date: 2016-08
Issue Date: 2017-09-29T02:17:14Z
Publisher: Journal of Applied Phycology
Abstract: Abstract:Fucoidans have been long used as a food supplement due to their diverse pharmacological effects on human health. Low molecular weight fucoidan (LF) is a common form of fucoidans that has been shown to have enhanced biological activity. In the present study, fucoidans were extracted from the brown alga Sargassum hemiphyllum and enzyme-hydrolyzed into low and high molecular weight fucoidans (HF). The skin protective effects of LF, HF, and other fucoidans derivatives against ultraviolet B (UVB) damage were determined by measuring the expression levels of matrix metalloproteinase genes encoding collagenases (MMP-1, MMP-2, MMP-8, MMP-9, MMP-13), transforming growth factor β receptor II (TGFβRII), and type I procollagen. The results show that LF protects against UVB damage to the skin by inhibiting UVB-induced transcription factor activator protein-1 (AP-1)-stimulated transcription of MMP genes encoding collagenases (MMP-1, MMP-8, and MMP-13) and increasing TGFβRII mRNA levels to prevent the loss of TGFβRII that occurs during UVB-induced collagen degradation. Moreover, this study reveals that the biological properties of fucoidans are highly dependent on the fucose content, sulfate content, and molecular weight.
Relation: 29(1), pp521-529
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43573
Appears in Collections:[生命科學系] 期刊論文

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