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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43557

Title: Biocompatibility analysis of NIH/3T3 cells exposed to silica-coated silver and silver nanoparticles
Authors: Lin, Chen-En;Rau, Lih-Rou;Liaw, Jiunn-Woei;Hsu, Fu-Yin;Tsai, Shiao-Wen
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Cell Viability;Imaging;Silica-Coated Silver Nanoparticles;Silver Nanoparticles
Date: 2016-12-01
Issue Date: 2017-09-21T07:59:47Z
Publisher: Nanoscience and Nanotechnology Letters
Abstract: Abstract:Despite the fact that silver nanoparticles (Ag NPs) have been used in widespread applications and that numerous studies have been performed to assess their cytotoxicity on various cell types, there is a lack of information regarding how to reduce the cytotoxicity of Ag NPs. Reduced or inhibited silver ions released from Ag NPs may promote their bioavailability in cells. In this study, we used silica-coated Ag NPs ([email protected]/* */2) in toxicity assays in vitro and compared the outcome with Ag NPs. In this study, NIH/3T3 cells were exposed for 30 min, 24 h, and 72 h to increasing concentrations of Ag NPs and [email protected]/* */2 NPs. The results showed that the viabilities of the cells were 51% and 41% after exposure to 10 μg/ml and 20 μg/ml of Ag NPs at 24 h post-exposure, respectively. For the same concentrations of [email protected]/* */2 particles, the viabilities were 91% and 74%, respectively. In addition, these NPs mostly located to the cytoplasm, not the nucleus, 72 h postexposure. Meanwhile, the cells treated with Ag NPs were less elongated than those treated with [email protected]/* */2 NPs. The data indicated that the silica coatings on the Ag NPs significantly decrease the cytotoxicity of the Ag NPs. Copyright © 2016 American Scientific Publishers. All rights reserved. Printed in the United States of America.
Relation: 8, pp.1080-1088
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43557
Appears in Collections:[生命科學系] 期刊論文

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