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题名: Epinecidin-1 peptide induces apoptosis which enhances antitumor effects in human leukemia U937 cells
作者: Chen JY;Lin WJ;Wu JL;Her GM;Hui CF
贡献者: 國立臺灣海洋大學:生命科學系
日期: 2009-08-29
上传时间: 2017-09-21T06:13:18Z
出版者: Peptides
摘要: Abstract:Epinecidin-1 is an antimicrobial peptide present in the grouper (Epinephelus coioides). In this study, the antitumor activity of a synthetic epinecidin-1 peptide was tested. The in vitro results showed that epinecidin-1 inhibited the proliferation of human leukemia U937 cells and increased the ADP/ATP ratio after 24h of treatment. The DNA fragmentation assay, flow cytometric assay, and caspases-3, -8, and -9 assays indicated that epinecidin-1 could induce apoptosis in U937 cells. Real-time RT-PCR results showed regular increases in tumor necrosis factor (TNF)-alpha after treatment with 4 microg/ml epinecidin-1 from 4 to 24h; interleukin (IL)-10, interferon (INF)-r, p53, IL-15, and IL-6 increased after treatment with 2 microg/ml epinecidin-1 for 4-12h. These results suggest that the epinecidn-1 inhibited U937 cells, induced apoptosis in response to cytokine production, and may have pleiotropic effects on different cells.
關聯: 30(12), pp.2365-2373
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43553
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