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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43547

Title: Evaluation of the epinecidin-1 peptide as an active ingredient in cleaning solutions against pathogens
Authors: Chieh-Yu Pan;Venugopal Rajanbabu;Jyh-Yih Chen;Guor Mour Herb;Fan-Hua Nan
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Epinecidin-1;Cleaning solution;Lytic peptide;Gram-negative bacteria;Gram-positive bacteria
Date: 2010-08
Issue Date: 2017-09-15T03:28:37Z
Publisher: Peptides
Abstract: Abstract:We tested the activity of epinecidin-1, a novel antimicrobial peptide structurally related to pleurocidin, in commercial cleaning solutions stored at 4 and 25 °C for 7 and 14 days. The peptide's activities against Enterococcus faecalis, Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, Propionibacterium acnes, and Candida albicans were measured in a minimum inhibitory concentration (MIC) determination, minimal bactericidal concentration (MBC) determination, disk diffusion test, and a count of the bacterial numbers. Exposure to epinecidn-1 in a cleaning solution following MIC value comparisons in the disk diffusion test and counts of bacterial numbers after 16, 24, 48, and 72 h suggested that bacterial numbers were much lower than those treated with only commercial cleaning solutions for all bacteria. The efficacy of the antimicrobial activities of inhibiting bacterial numbers by epinecidin-1 in cleaning solutions at a low pH and a low temperature was not affected. Given its simple structure and antimicrobial activity, epinecidin-1 may be a useful component of microbicides designed to prevent pathogen infections and/or remediate abnormal vaginal or skin flora.
Relation: 31(8), pp.1449-1458
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43547
Appears in Collections:[生命科學系] 期刊論文

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