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Title: Preparation and characterization of mesoporous bioactive glass from agricultural waste rice husk for targeted anticancer drug delivery
Authors: Shiow-Yi Chen
Po-Fong Chou
Wai-Kong Chan
Hsiu-Mei Lin
Contributors: 國立臺灣海洋大學:生命科學系
Keywords: Rice husk;Mesoporous bioactive glassFolic acid;FA receptor
Date: 2017-02
Issue Date: 2017-09-07T06:35:36Z
Publisher: Ceramics International
Abstract: Abstract:Mesoporous bioactive glass (MBG) possesses excellent biocompatibility and an important material used for bone regeneration and drug delivery. The aim of this study is to synthesize MBG from low-cost agricultural waste rice husk (rMBG) using a sol-gel process. We show that rMBG has typical characteristics of the well-ordered hexagonal mesostructure of MBG and can be grafted with folic acid (FA) and then loaded with anticancer drugs for targeting cancer cells. By loading rMBG-FA with camptothecin (CPT, a water-insoluble anticancer drug) we formed rMBG-FA/CPT, which killed cancer cells by being selectively and efficiently taken in via the cells’ FA receptors (FRs). We found that rMBG-FA/CPT showed a higher cytotoxicity to FR-overexpressed HeLa cells than to FR-deficient L929 cells. Our results indicate that low-cost rMBG offers a potentially practical medical application that can replace highly valuable MBG as well as reduce environmental pollution caused by agricultural waste.
Relation: 43(2), pp.2239-2245
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43530
Appears in Collections:[生命科學系] 期刊論文

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