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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43354

Title: Enhanced anti-inflammatory activity of brown seaweed Laminariajaponica by fermentation using Bacillus subtilis
Authors: Hong-Ting Victor Lin;Wen-Jung Lu;Guo-Jane Tsai;Chein-Te Chou;Hsin-I Hsiao;Pai-An Hwang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Bacillus subtilisLaminaria japonica;Fermentation;Anti-inflammation;NO reduction
Date: 2016-12
Issue Date: 2017-07-11T01:52:17Z
Publisher: Process Biochemistry
Abstract: Abstract:Most studies on the anti-inflammatory effects of Laminaria japonica have investigated bioactive ingredients that have been extracted from Laminaria using organic solvents. However, to avoid the toxicity and environmental issues caused by the solvent used for extraction, increasing attention has focused on fermentation using microorganisms as a green bioconversion process for producing bioactive compounds. In this study, fermentation with Bacillus subtilis, where the cultivation parameters and nutrient additives were optimized to achieve the greatest inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production, was found to enhance the anti-inflammatory effects of L. japonica. Fermentation by B. subtilis using a 5% (w/v) L. japonica suspension as the sole carbon source, 2% additional nitrogen source, a starting pH of 6, and incubation at 150 rpm at 37 °C for 72 h yielded the best anti-inflammatory effects, as LPS-induced NO production decreased to 27.6% ± 5.2%. The macrophages treated with the fermented L. japonica product inhibited the LPS-induced production of reactive oxygen species (ROS) and NF-κB (p65) phosphorylation in a concentration-dependent manner. Thus, our results show that L. japonica products generated by an optimized fermentation process designed to enhance anti-inflammatory effects by decreasing ROS production, NF-κB (p65) phosphorylation, prostaglandin E2, and NO production in macrophages.
Relation: 51(12), pp.1945-1953
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43354
Appears in Collections:[食品科學系] 期刊論文

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