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题名: 2D-DIGE proteome analysis on the platelet proteins of patients with major depression
作者: Tiao-Lai Huang;Mei-Lan Sung;Tai-Yuan Chen
贡献者: 國立臺灣海洋大學:食品科學系
关键词: 2D-DIGE;Western blot;Major depression;Platelet;Fibrinogen
日期: 2014-01
上传时间: 2017-07-04T06:05:24Z
出版者: Proteome Science
摘要: Abstract:
Introduction
Platelet activation is related to the psychopathology of major depression. We attempted to search and identify protein biomarkers from the platelets of patients with major depression. High resolution two-dimensional Differential Gel Electrophoresis (2D-DIGE), the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), Western blot, and bioinformatic tools were applied to examine the platelet proteins of 10 patients with major depression and 10 healthy controls.
Results
The levels of 8 proteins were significantly different between the patients with major depression in the acute phase and healthy controls. The levels of protein disulfide-isomerase A3 (PDIA3) and F-actin-capping protein subunit beta (CAPZB) were higher in patients with major depression than in healthy controls. The levels of fibrinogen beta chain (FIBB), fibrinogen gamma chain (FIBG), retinoic acid receptor beta (RARB), glutathione peroxidase 1 (GPX1), SH3 domain-containing protein 19 (SH319), and T-complex protein 1 subunit beta (TCPB) were lower in patients with major depression than in healthy controls. Conclusions
Platelet provided valuable information about the pathways and processes of inflammation/immunity, oxidative stress, and neurogenesis, related to major depression.
關聯: 12(1), pp.1-9
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43318
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