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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43317

Title: Inhibitory effect of aqueous extracts from Miracle Fruit leaves on mutation and oxidative damage
Authors: Tai-Yuan Chen;Zhi-Chyang Kang;Ming-Tsung Yen;Ming-Hsing Huang;Bor-Sen Wang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: HPLC;Miracle Fruit leaves;Mutation;Oxidation
Date: 2015-02-15
Issue Date: 2017-07-04T05:53:36Z
Publisher: Food Chemistry
Abstract: Abstract:This study investigated the inhibitory effects of aqueous extracts from Miracle Fruit leaves (AML) on mutation and oxidative damage. The results showed that AML in the range of 1-5mg/plate inhibited the mutagenicity of 2-aminoanthracene (2-AA), an indirect mutagen, and 4-nitroquinoline-N-oxide (4-NQO), a direct mutagen toward Salmonella typhimurium TA 98 and TA 100. On the other hand, AML in the range of 0.05-0.2mg/ml showed radical scavenging, reducing activities, liposome protection as well as decreased tert-butyl hydroperoxide (t-BHP) induced oxidative cytotoxicity in HepG2 cells. High performance liquid chromatography (HPLC) analysis suggested that the active phenolic constituents in AML are p-hydroxybenzoic acid, vanillic acid, syringic acid, trans-p-coumaric acid and veratric acid. These active phenolic components may contribute to the biological protection effects of AML in different models. The data suggest that AML exhibiting biological activities can be applied to antimutation as well as anti-oxidative damage.
Relation: 169, pp.411-416
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/43317
Appears in Collections:[食品科學系] 期刊論文

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