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|Title: ||A novel reusable nanomechanics-based protein biosensor with electrical manipulation|
|Authors: ||R.-Z. Hwang;L.-S. Huang;H.-S. Chang;C.-W. Wu;H.-C. Tien;S. Lin;A.S.-Y. Lee|
|Issue Date: ||2017-06-08T01:52:49Z
|Publisher: ||Micro Electro Mechanical Systems, 2005. MEMS 2005. 18th IEEE International Conference on|
|Abstract: ||Abstract::A novel reusable biosensor of label-free biomolecular recognition based on the nanomechanics transduction in a micro-fabricated cantilever has been developed. The nanomechanics-based immunoassay biosensor was proven to be repeatedly used with desorption of the pre-bound antigen-antibody by an in-situ alternative electrical field. This new approach of electric manipulation in separating the antigen out of the antibody in a buffer fluid environment was confirmed in nanomechanics-based immunoassay biosensor in which a conventional desorption is long used with high concentrated acid solution in a range of pH 2/spl sim/3. The potential benefit of the electrical means over a conventional pre-bound antigen-antibody desorption of strong acid solution is to maintain long-standing protein activity in multiple uses such that the micro biosensor is reliable and reproducible in every detection. The complete sensing history from a monolayer of biolinker, to antibody and antigen is also first demonstrated in nanomechanics-based immunoassay.|
|Appears in Collections:||[機械與機電工程學系] 期刊論文|
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