English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26988/38789
Visitors : 2346743      Online Users : 36
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/41840

Title: Oxidized dopamine as the interlayer between heparin/collagen polyelectrolyte multilayers and titanium substrate: An investigation of the coating's adhesion and hemocompatibility
Authors: Chau-Chang Chou;Shang-Wen Hsin;Hou-Cheng Lin;Chi-Hsiao Yeh;Rudder Wu;Wen-Jin Cherng
Contributors: 國立臺灣海洋大學:機械與機電工程學系
Keywords: Dopamine;Hemocompatibility;Adhesion;Heparin;Titanium
Date: 2016-10
Issue Date: 2017-04-06T01:34:16Z
Publisher: Surface and Coatings Technology
Abstract: Abstract:To improve the adhesion and blood-compatibility of the titanium substrate coated with heparin/collagen multilayers, an oxidized dopamine was applied as the interlayer between the multilayers and the substrate. The oxidation condition of the dopamine interlayer was achieved by treating the dopamine solution under an atmospheric environment for 8 h. A dopamine interlayer built in a pure nitrogen environment was used as a benchmark. 4 and 9 multilayers were also built and studied for both samples. The film thickness was evaluated by the cross-sectional technique of focused ion beam microscopy. The hydrophilicity and surface topography of the films were investigated by water contact angle measurement and scanning electron microscopy. The adhesion of the multilayers was studied with scratch tests. The amount of heparin that attached to the samples was measured by toluidine blue O test. The hemocompatibility was verified by the platelet coverage area, activated partial thromboplastin time, and hemolysis ratio in vitro. The results indicated that the oxidized dopamine not only enhanced the uniformity and thickness of heparin/collagen multilayers on a titanium substrate but also promoted the sample's adhesion and hemocompatibility, especially that with a larger number of multilayers.
Relation: 303, pp.277-282
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/41840
Appears in Collections:[機械與機電工程學系] 期刊論文

Files in This Item:

There are no files associated with this item.



All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback