National Taiwan Ocean University Institutional Repository:Item 987654321/40193
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 28611/40652
造访人次 : 754515      在线人数 : 50
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 进阶搜寻

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/40193

题名: Homologous synteny block detection based on suffix tree algorithm
作者: Yu-Lun Chen;Chien-Ming Chen;Tun-Wen Pai
贡献者: 國立臺灣海洋大學:資訊工程學系
日期: 2013
上传时间: 2017-01-16T03:39:58Z
出版者: Journal of Bioinformatics and Computational Biology
摘要: Abstract: A synteny block represents a set of contiguous genes located within the same chromosome and well conserved among various species. Through long evolutionary processes and genome rearrangement events, large numbers of synteny blocks remain highly conserved across multiple species. Understanding distribution of conserved gene blocks facilitates evolutionary biologists to trace the diversity of life, and it also plays an important role for orthologous gene detection and gene annotation in the genomic era. In this work, we focus on collinear synteny detection in which the order of genes is required and well conserved among multiple species. To achieve this goal, the suffix tree based algorithms for efficiently identifying homologous synteny blocks was proposed. The traditional suffix tree algorithm was modified by considering a chromosome as a string and each gene in a chromosome is encoded as a symbol character. Hence, a suffix tree can be built for different query chromosomes from various species. We can then efficiently search for conserved synteny blocks that are modeled as overlapped contiguous edges in our suffix tree. In addition, we defined a novel Synteny Block Conserved Index (SBCI) to evaluate the relationship of synteny block distribution between two species, and which could be applied as an evolutionary indicator for constructing a phylogenetic tree from multiple species instead of performing large computational requirements through whole genome sequence alignment.
關聯: 11(6)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/40193
显示于类别:[資訊工程學系] 期刊論文

文件中的档案:

档案 描述 大小格式浏览次数
index.html0KbHTML85检视/开启


在NTOUR中所有的数据项都受到原著作权保护.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈