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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39955

Title: Biotransformation of taxol
Authors: Tom S. Chen;Xiaohua Li;Dan Bollag;Yeuh-chuen Liu;Ching-jer Chang
Contributors: 國立臺灣海洋大學:食品科學系
Date: 2001
Issue Date: 2017-01-10T08:55:27Z
Publisher: Tetrahedron Letters
Abstract: Abstract: Abstract
Bioconversion of taxol/cephalomannine by Streptomyces sp. MA 7065 resulted in hydroxylation on the 10-acetyl methyl group in 60% yield and on the benzene ring at the para position of the phenylisoserine side chain in 10% yield. This culture could also hydroxylate the allylic methyl group of the phenylisoserine side chain of cephalomannine quantitatively. All three metabolites were cytotoxic toward human lung, breast and colon tumor cell lines.

Bioconversion of taxol by Streptomyces sp. MA 7065 resulted in hydroxylation on the 10-acetyl methyl group in 60% yield and on the benzene ring at the para position of the phenylisoserine side chain in 10% yield.
Relation: 42(23)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39955
Appears in Collections:[食品科學系] 期刊論文

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