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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39824

Title: Nano Zerovalent Iron Particles Induce Pulmonary and Cardiovascular Toxicity in an in Vitro Human Co-culture Model
Authors: Zhelin Sun
Lingyan Yang
Ku-Fan Chen
Guan-Wen Chen
Yen-Ping Peng
Jen-Kun Chen
Guangli Suo
Jiantao Yu
Wen-Cheng Wang
Chia-Hua Lin
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: oxidative stress
epithelial barrier integrity
Date: 2015-12
Issue Date: 2017-01-03T07:24:27Z
Publisher:  Nanotoxicology
Abstract: Abstract: Despite promising environmental applications for nano zerovalent iron (nZVI), concerns remain about the potential accumulation and toxic effects of nZVI particles. Here, we use an alveolar-capillary co-culture model to investigate a possible link between low-level epithelial exposure to nZVI and pulmonary and cardiovascular toxicity. While nZVI was unable to pass through the epithelial barrier into the endothelium, nZVI exposure did cause oxidative and inflammatory responses in both epithelial and endothelial cells. Therefore, toxic effects induced by nZVI are not restricted to epithelial cells but can be transferred into the endothelium. Communication between A549 and EA.hy926 cells is responsible for amplification of nZVI-induced toxic responses. Decreases in transepithelial electrical resistance and zonula occludens proteins after epithelial exposure to nZVI impaired epithelial barrier integrity. Increases in oxidized α1-antitrypsin and oxidized low-density lipoprotein in the co-culture model suggest that nZVI exposure increases the risk of chronic obstructive pulmonary disease and atherosclerosis. Therefore, inhalation of nZVI has the potential to induce cardiovascular disease through oxidative and inflammatory mediators produced from the damaged lung epithelium in chronic lung diseases.
Relation: 10(7)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39824
Appears in Collections:[食品科學系] 期刊論文

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