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题名: A PBTK/TD modeling-based approach can assess arsenic bioaccumulation in farmed tilapia Oreochromis mossambicus and human health risks
作者: Min-Pei Ling
Chung-Min Liao
Jeng-Wei Tsai
Bo-Ching Chen
贡献者: 國立臺灣海洋大學:食品科學系
关键词: Tilapia
Human health risk
Model-based risk assessment
日期: 2005-02
上传时间: 2016-12-28T08:25:35Z
出版者: Integrated Environmental Assessment and Management
摘要: Abstract: A biologically based risk-assessment model of arsenic (As) exposure evaluated farmed tilapia (Orechromis mossambicus) and human health during tilapia consumption in an area of southwestern Taiwan where blackfoot disease (BFD) occurs. The risk assessment addressed exposures to city residents who lived in Taipei, Taichung, and Kaohsiung, as well as subsistence fishers living in the BFD area who consumed tilapia. The models implemented included a physiologically based toxicokinetic and toxicodynamic (PBTK/TD) model to account for As exposure and dose-response profiles in tilapia and a human health exposure/risk model that accounts for target lifetime risk (TR) and hazard quotient (HQ) for humans consuming farmed tilapia. Results demonstrated that 90th percentiles of TR ranged from 1.53 × 10−8 to 1.62 × 10−6 for city residents with farmed tilapia consumption rates of 0.41 to 1.37 g/d. The 90th percentiles ranged from 2.07 × 10−6 to 7.89 × 10−5 for subsistence fishers in the BFD area with farmed tilapia consumption rates of 16.80 to 59.15 g/d. All predicted 90th percentiles of HQ were less than 1 for city residents and subsistence fishers in the BFD area, indicating small contributions from farmed tilapia consumption. Critical variables included whole-fish body weight, water As content, and As level in tilapia muscle. Although bioaccumulation of As seems unlikely to result in toxicity to farmed tilapia and humans consuming tilapia, the theoretical human health risks in the BFD area are alarming, using a probabilistic risk-assessment model based on conservative assumptions.
關聯: 1(1)
显示于类别:[食品科學系] 期刊論文


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