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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39697

Title: Use of seasonal influenza virus titers combined with respiratory symptom scores to estimate effective human contact rates
Authors: Chung-Min Liao
Shu-Han You
Szu-Chieh Chen
Min-Pei Ling
Chia-Pin Chio
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: modeling
influenza
behavior
contact rate
symptom score
Date: 2012
Issue Date: 2016-12-28T03:51:04Z
Publisher: Journal of Epidemiology
Abstract: Abstract:

Background
We linked viral titers and respiratory symptom scores for seasonal influenza to estimate the effective contact rate among schoolchildren.

Methods
We analyzed 274 diary-based questionnaires. In addition, 2 sets of influenza data from published studies were used to investigate the relationship between viral titer, total symptom score, and normalized contact rate in children.

Results
The mean number (SD) of contacts for children in grades 7 to 9 ranged from 9.44 ± 8.68 to 11.18 ± 7.98 person−1 day−1; contact behavior was similar across school grades. The mean number of contacts was 5.66 ± 6.23 person−1 day−1 (range, 0 to 44 person−1 day−1) for the age group of 13 to 19 years. Estimated contact age, household size, contact duration, and contact frequency were the variables most strongly associated with total number of contacts. We also found that a reduction in total respiratory symptom scores among infected individuals had a positive correlation with an increase in the normalized contact rate.

Conclusions
The relationship between daily virus titer and respiratory symptom score can be used to estimate the effective contact rate in explaining the spread of an airborne transmissible disease. The present findings can be incorporated into population-dynamic models of influenza transmission among schoolchildren.
Relation: 22(4)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39697
Appears in Collections:[食品科學系] 期刊論文

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