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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39685

Title: Cembrane Derivatives from the Soft Corals Sinularia gaweli and Sinularia flexibilis.Marine Drugs
Authors: Wei-Hsuan Yen
Li-Chung Hu
Jui-Hsin Su
Michael Yen-Nan Chiang
Zhi-Hong Wen
Wu-Fu Chen
Ting-Jang Lu
Yu-Wei Chang
Yung-Husan Chen
Wei-Hsien Wang
Yang-Chang Wu
Ping-Jyun Sung
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: anti-inflammatory activity
cembrane
norcembrane
Sinularia flexibilis
Sinularia gaweli
X-ray
Date: 2013-06
Issue Date: 2016-12-28T01:59:58Z
Publisher:  Marine Drugs
Abstract: Abstract: A new norcembranoidal diterpene, 1-epi-sinulanorcembranolide A (1), and a new cembranoidal diterpene, flexibilin D (2), were isolated from the soft corals, Sinularia gaweli and Sinularia flexibilis, respectively. The structures of new metabolites 1 and 2 were elucidated by spectroscopic methods, and compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. In addition, S. flexibilis yielded a known cembrane, 5-dehydrosinulariolide (3); the structure, including its absolute stereochemistry, was further confirmed by single-crystal X-ray diffraction analysis.
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Relation: 11(6)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39685
Appears in Collections:[食品科學系] 期刊論文

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