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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39444

Title: Effects of sizes and conformations of fish scale collagen peptides (FSCPs) on facial skin qualities and transdermal penetration efficiency
Authors: Chang-Jer Wu
Jing-Hua Li
Huey-Jine Chai
Han-Ning Huang
Tsung-Lin Li
Yi-Lin Chan
Chyuan-Yuan Shiau
Contributors: 國立臺灣海洋大學:食品科學系
Date: 2010-06
Issue Date: 2016-12-12T08:20:30Z
Publisher: Journal of Biomedicine and Biotechnology
Abstract: Abstract: Fish-scale collagen peptides (FSCPs) were prepared using a given combination of proteases to hydrolyze tilapia (Oreochromis sp.) scales. FSCPs were determined to stimulate fibroblast cells proliferation and procollagen synthesis in a time- and dose-dependent manner. The transdermal penetration capabilities of the fractionationed FSCPs were evaluated using the Franz-type diffusion cell model. The heavier FSCPs, 3500 and 4500 Da, showed higher cumulative penetration capability as opposed to the lighter FSCPs, 2000 and 1300 Da. In addition, the heavier seemed to preserve favorable coiled structures comparing to the lighter that presents mainly as linear under confocal scanning laser microscopy. FSCPs, particularly the heavier, were concluded to efficiently penetrate stratum corneum to epidermis and dermis, activate fibroblasts, and accelerate collagen synthesis. The heavier outweighs the lighter in transdermal penetration likely as a result of preserving the given desired structure feature.
Relation: 2010
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39444
Appears in Collections:[食品科學系] 期刊論文

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