National Taiwan Ocean University Institutional Repository:Item 987654321/39372
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 27308/39152
造访人次 : 2447772      在线人数 : 41
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 进阶搜寻

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39372

题名: Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast
作者: Chang-Jer Wu
Hang Wang
Yi-Lin Chan
Tsung-Lin Li
Brent A. Bauer
Cheng-Hsu Wang
Simon Hsia
Jen-Seng Huang
Hung-Ming Wang
Kun-Yun Yeh
Tse-Hung Huang
Gwo-Jang Wu
贡献者: 國立臺灣海洋大學:食品科學系
日期: 2013
上传时间: 2016-12-07T08:03:23Z
出版者: PLoS One
摘要: Abstract: Growing evidence has shown that regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) abnormally increase in cancer cachectic patients. Suppressions of Tregs and MDSCs may enhance anti-tumor immunity for cancer patients. Fish oil and selenium have been known to have many biological activities such as anti-inflammation and anti-oxidation. Whether fish oil and/or selenium have an additional effect on population of immunosuppressive cells in tumor-bearing hosts remained elusive and controversial. To gain insights into their roles on anti-tumor immunity, we studied the fish oil- and/or selenium-mediated tumor suppression and immunity on lung carcinoma, whereof cachexia develops. Advancement of cachexia in a murine lung cancer model manifested with such indicative symptoms as weight loss, chronic inflammation and disturbed immune functionality. The elevation of Tregs and MDSCs in spleens of tumor-bearing mice was positively correlated with tumor burdens. Consumption of either fish oil or selenium had little or no effect on the levels of Tregs and MDSCs. However, consumption of both fish oil and selenium together presented a synergistic effect--the population of Tregs and MDSCs decreased as opposed to increase of anti-tumor immunity when both fish oil and selenium were supplemented simultaneously, whereby losses of body weight and muscle/fat mass were alleviated significantly.
關聯: 8(1)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39372
显示于类别:[食品科學系] 期刊論文

文件中的档案:

档案 描述 大小格式浏览次数
index.html0KbHTML68检视/开启


在NTOUR中所有的数据项都受到原著作权保护.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈