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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39358

Title: Prophylactic administration of fucoidan represses cancer metastasis by inhibiting vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPS) in Lewis tumor-bearing mice
Authors: Tse-Hung Huang
Yi-Han Chiu
Yi-Lin Chan
Ya-Huang Chiu
Hang Wang
Kuo-Chin Huang
Tsung-Lin Li
Kuang-Hung Hsu
Chang-Jer Wu
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: chemo-preventative agent
fucoidan
sulfated polysaccharide
lung carcinoma
metastasis
cachexia
Date: 2015-04
Issue Date: 2016-12-07T03:51:03Z
Publisher: Marine drugs
Abstract: Abstract: Fucoidan, a heparin-like sulfated polysaccharide, is rich in brown algae. It has a wide assortment of protective activities against cancer, for example, induction of hepatocellular carcinoma senescence, induction of human breast and colon carcinoma apoptosis, and impediment of lung cancer cells migration and invasion. However, the anti-metastatic mechanism that fucoidan exploits remains elusive. In this report, we explored the effects of fucoidan on cachectic symptoms, tumor development, lung carcinoma cell spreading and proliferation, as well as expression of metastasis-associated proteins in the Lewis lung carcinoma (LLC) cells-inoculated mice model. We discovered that administration of fucoidan has prophylactic effects on mitigation of cachectic body weight loss and improvement of lung masses in tumor-inoculated mice. These desired effects are attributed to inhibition of LLC spreading and proliferation in lung tissues. Fucoidan also down-regulates expression of matrix metalloproteinases (MMPs), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and vascular endothelial growth factor (VEGF). Moreover, the tumor-bearing mice supplemented with fucoidan indeed benefit from an ensemble of the chemo-phylacticity. The fact is that fucoidan significantly decreases viability, migration, invasion, and MMPs activities of LLC cells. In summary, fucoidan is suitable to act as a chemo-preventative agent for minimizing cachectic symptoms as well as inhibiting lung carcinoma metastasis through down-regulating metastatic factors VEGF and MMPs.
Relation: 13(4)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39358
Appears in Collections:[食品科學系] 期刊論文

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