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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39357

Title: Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium
Authors: Chang-Jer Wu
Hang Wang
Tsung-Lin Li
Simon Hsia
I-Li Su
Yi-Lin Chan
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: selenium
cachexia
chemotherapy
fish oil
muscle atrophy
Date: 2015-04
Issue Date: 2016-12-07T03:32:20Z
Publisher: Oncotarget
Abstract: Abstract: Chemotherapy can cause cachexia, which is manifested by weight loss, inflammation and muscle atrophy. However, the mechanisms of tumor and chemotherapy on skeletal muscle proteolysis, remained unclear. In this report, we demonstrated that tumor-induced myostatin in turn induced TNF-α, thus activating calcium-dependent and proteasomal protein degradation. Chemotherapy activated myostatin-mediated proteolysis and muscle atrophy by elevating IL-6. In tumor-bearing mice under chemotherapy, supplementation with fish oil and selenium prevented a rise in IL-6, TNF-α and myostatin and muscle atrophy. The findings presented here allow us to better understand the molecular basis of cancer cachexia and potentiate nutrition supplementation in future cancer chemotherapy.
Relation: 6(10)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39357
Appears in Collections:[食品科學系] 期刊論文

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