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Title: Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice
Authors: Tse-Hung Huang
Yi-Han Chiu
Yi-Lin Chan
Hang Wang
Tsung-Lin Li
Chien-Yin Liu
Cheng-Ta Yang
Tzung-Yan Lee
Jyh-Sheng You
Kuang-Hung Hsu
Chang-Jer Wu
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: lung cancer
antrodia cinnamomea
Date: 2015-09
Issue Date: 2016-12-07T02:27:10Z
Publisher: Oncotarget
Abstract: Abstract: Whereas cisplatin (cis-diamminedichloroplatinum II) is a first-line medicine to treat solid cancerous tumors, it often causes serious side effects. New medicines that have an equivalent or even better therapeutic effect but with free or less side effects than cisplatin are highly anticipated in cancer therapy. Recent reports revealed that Antrodia cinnamomea (AC) possesses hepatoprotective activity in addition to anticancer. In this study, we wanted to know whether AC enhances chemo-sensitivity of cisplatin and/or alleviates cisplatin-induced hepatotoxicity, as well as the underlying mechanisms thereof. Our results indicated that AC inhibited proliferation of line-1 lung carcinoma cells and rescued hepatic HepG2 cells from cisplatin-induced cell death in vitro. The fact is that AC and cisplatin synergized to constrain growth of line-1 lung carcinoma cells in BALB/cByJ mice. Quantitative real-time PCR further revealed that AC promoted expression of apoptosis-related genes, while it decreased expression of NF-κB and VEGF in tumor tissues. In liver, AC reduced cisplatin-induced liver dysfunctions, liver inflammation and hepatic apoptosis in addition to body weight restoration. In summary, AC is able to increase cisplatin efficacy by triggering expression of apoptosis-related genes in line-1 lung cancer cells as well as to protect liver from tissue damage by avoiding cisplatin-induced hepatic inflammation and cell death.
Relation: 6(28)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39350
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