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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39234

Title: Study on the Toxicity of the Extracellular Mucilage from Klebsiella oxytoca CF154
所產胞外黏性物質毒性之探討
Authors: 汪復進
吳清熊
潘崇良
Fu-Jin Wang
Ching-Shung Wu
Chorng-Liang Pan
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Toxicity
Ames氏偵測法
胞外黏性物質凍乾粉末
化學變異性
Micronucleus test
Klebsiella
Lyophilized extracellular mucilage (LEM)
Ames test
Mutagenicity
Micronucleus test
Date: 2009-12
Issue Date: 2016-11-29T08:25:55Z
Publisher: 臺灣水產學會刊
Abstract: Abstract: The lyophilized extracellular mucilage (LEM) extracted from Kebsiella oxytoca CF154 was subjected to a series of toxicological tests to evaluate its safety for use in various foods in the future. LEM was examined for acute and subchronic oral toxicity by using Wistar rats, and for mutagenic potential by using the Ames test using Salmonella typhimurium, and the micronucleus test by using male ICR mice. No evidence was obtained showing acute oral toxicity at a LEM concentration from 0.1% to 3.0% (w/w) in this test, nor was there any mutagenicity exhibited up to a concentration of 3.0% with and without metabolic activation (S-9 mixture). The micronucleus test showed no obvious positive response either. Using LEM as a dietary mixture at levels of 1.0%, 2.0%, and 3.0% (w/w) for feeding the rats for 12 weeks did not show any inducible signs of toxicity. The result of this study indicates that there is a lack of toxicity and supports the use of LEM extract from K. oxytoca CF154 under a concentration of 3.0% or less for a variety of foods.
Relation: 36(4)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39234
Appears in Collections:[食品科學系] 期刊論文

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