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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39044

Title: Amplification of enantioselectivity in biocatalyzed kinetic resolution of racemic alcohols
Authors: Ching Shih Chen;Yeuk Chuen Liu
Contributors: 國立臺灣海洋大學:食品科學系
Date: 1991
Issue Date: 2016-11-22T08:40:51Z
Publisher: J. Org. Chem
Abstract: Abstract: Recently, much effort in the field of asymmetric biocatalyais has been directed toward identifying lipases with useful enantioselectivity against a broad array of organic compounds.' For many unnatural substrates, the catalysis is often effected with low to moderate selectivity, yielding products with enantiomeric exceea ranging from 0.5 to 0.8. To improve the enantiomeric discrimination, several strategies have been proposed which entail physical and/or chemical manipulations of enzyme preparations. Presumably, these treatments led to selectivity enhancement by diminishing competing reactions caused by contaminating enzymes2 or by altering enzyme molecules to assume new ~onformation.~ More recently, Sih and his co-workers have proposed a useful concept of "sequential biocatalytic re~olution"~ in the preparation of axially disymmetric diols such as binaphthol and threo-2,4-pentanediol with high optical purity. As these molecules possess two functional sites for enzymatic action, the synergistic coupling of two consecutive enantiospecific steps allows stereoselectivity enhancement.
Relation: 56(5)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/39044
Appears in Collections:[食品科學系] 期刊論文

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