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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38933

Title: Bile acid composition in the snake bile juice and toxicity of snake bile acids on rats
Authors: Yeh YH;Wang DY;Liau MY;Wu ML;Deng JF;Noguchi T;Hwang DF
Contributors: 國立臺灣海洋大學:食品科學系
Date: 2003-11
Issue Date: 2016-11-16T03:14:28Z
Publisher: Comp Biochem Physiol C Toxicol Pharmacol
Abstract: Abstract: We determined the bile acid profiles in bile juice of snake gallbladders by HPLC on a silica gel RP-18 reversed-phase column. Cholic acid and chenodeoxycholic acid were predominant components in three of four snake species. To elucidate the toxic effect of snake bile acids on rats, a synthetic bile acid mixture was prepared mimicking the bile acid composition of a snake Naja naja atra bile juice. Twenty-four male Wistar rats were divided into four groups and treated orally at 3-day intervals with saline (control group) and different doses (1-3x doses) of the bile acid mixture. After treatment, the following parameters increased: the relative ratios of liver and kidney mass to body mass, the concentrations of red blood cell, hemoglobin and hematocrit in the blood, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, plasma urea nitrogen and creatinine in the plasma, and the levels of urine urea nitrogen and creatinine in the urine. Body mass of rats and the levels of Na+, K+, Ca++ in the urine of rats were significantly decreased, especially for groups treated with 2x and 3x doses of the bile acid mixture. Examination of liver and kidney pathology also showed cell enlargement and lesion in cell integrity in treated groups, especially for groups treated with 2x and 3x bile acid mixture, indicating that short-term toxicity of snake N. naja atra bile acids was significant in rats.
Relation: 136(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/38933
Appears in Collections:[食品科學系] 期刊論文

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